Thrombin Time Reagent

A thrombin time is necessary in isolation or in conjunction with other tests when you encounter instances of bleeding or clotting, suffer from recurrent miscarriages, or exhibit unexplained prolonged outcomes on primary coagulation tests like prothrombin time (PT) or partial thromboplastin time (PTT). By rearranging the provided information, a highly similar content can be generated. However, it must be noted that the content generated should be based on the original text information and not follow the conversation-style of ChapGPT.
UD-Bio, a leading manufacturer, produces the Thrombin Time reagent. This reagent is specifically designed for determining the thrombin time (TT) in human plasma using the clotting method. It is widely adaptable and can be used on the Automatic Coagulation System UD-C2000 as well as various coagulation analyzer systems across the globe. Rest assured, this reagent guarantees accurate and efficient results for thrombin time analysis.

Specification:

Principle Method
The formation of a clot occurs when thrombin converts fibrinogen, found in the plasma, into fibrin. To measure the time it takes for a clot to form, the thrombin time is determined. This method is particularly useful for assessing clot formation.

Therapy with high-molecular weight heparins requires careful monitoring to ensure its effectiveness and safety. This includes regular assessment of blood parameters, such as activated partial thromboplastin time (aPTT) and anti-Xa activity levels. Monitoring allows healthcare professionals to adjust the dosage of high-molecular weight heparins based on individual patient needs and response to treatment. It also helps in identifying any potential complications or adverse effects associated with the therapy. Therefore, close monitoring plays a crucial role in optimizing the outcomes of high-molecular weight heparin therapy.

√ Monitoring of fibrinolytic therapy.

Severe cases of fibrinogen deficiency disorders or abnormal fibrin formation can be detected through proper screening. It is important to identify such conditions early on in order to initiate appropriate treatment.

The distinction between heparin-induced prolongation of the thrombin time and disorders of fibrinogen formation can be established based on various factors. Heparin-induced prolongation of the thrombin time refers to a condition in which the presence of heparin in a patient's blood leads to an extended thrombin time. This occurs due to the inhibition of thrombin by heparin, resulting in the prevention of clot formation. On the other hand, disorders of fibrinogen formation involve abnormal production or functioning of fibrinogen, a protein essential for clot formation. These disorders can be congenital or acquired, and they can affect the production, stability, or structure of fibrinogen, leading to impaired clotting ability. Differentiating between these two conditions requires careful evaluation of factors such as patient history, laboratory tests, and possibly additional diagnostic procedures. It is crucial for healthcare professionals to accurately identify the underlying cause of prolonged thrombin time in order to provide appropriate treatment and management strategies for patients.

The presence of heparin can cause a prolonged thrombin time, which is not only attributed to fibrin polymerization disorders. It is essential to note that heparin can also contribute to this outcome.

Thrombin Time reagent Composition:
The TT Reagent consists of several carefully selected ingredients, including NaCl in concentrations no higher than 0.5%, Tris(hydroxymethyl)aminomethane in quantities of no more than 1%, and mannitol levels kept below 10%. The superbly effective thrombin, present in concentrations of no less than 10 IU/mL, guarantees exceptional results every time. Finally, a preservative is added in amounts no greater than 0.1% to ensure product quality and longevity. All of these components work together in perfect harmony to create a one-of-a-kind reagent that is second to none.

Thrombin Time reagent Preparation:
Sample: Plasma 50 ul
Incubate for 60 seconds at 37℃.
Thrombin Time reagent:100 μL
Mix well, then determine the coagulation time.

Performance Characteristics:
The defined range is used as a benchmark to measure the accuracy of the controls being tested. The expected outcome is for the results to fall within this range, indicating a high level of precision and reliability in the testing process. It is important to ensure accurate results in order to make informed decisions based on the data gathered.
Intra-assay precision: CV ≤4%.
Inter-batch Deviation: CV ≤8%.
The stability of our reagents is of utmost importance, which is why we can guarantee that unopened products will remain stable for at least two years when stored within the optimal temperature range of 2-8℃. Even at the end of the two-year shelf life, you can expect our products to perform just as well as when you first received them, adhering to the specifications outlined in the original text.

Expected Values:
14~21(s)

Storage and Stability:
Storage: 2~8 ℃, do not freeze.
Closed Vial Expiry: 24 months.
After dissolving, the TT reagent remains stable for a period of 7 days at a temperature range of 2~8℃.

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